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Paclitaxel-loaded hyaluronan solid nanoemulsions (PTX-HSNs) were successfully fabricated for the delivery of PTX to improve ovarian cancer treatment via active tumor targeting. The in vivo #toxicity,

Liver cancer is the fourth greatest cause of cancer related mortality. AD80 is a multi-kinase inhibitor with anti-tumoral activity across a variety of hepatocellular carcinoma (HCC) preclinical models

Phosphodiesterase-1 (PDE1) is a promising drug target closely related to central and peripheral diseases. Compound 2j with the IC50 of 21 nM against PDE1B, shows good metabolic stability in the rat li

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Nonalcoholic steatohepatitis (NASH) is the advanced subtype of nonalcoholic fatty liver disease (NAFLD) and is becoming a severe global public health problem. PPARα/δ are regarded as potential therape

The binding assay by surface plasmon resonance (SPR) analysis shows that WYC-209A and WYC-209B acid bind to RARs at nano-molar doses. SPR was carried out by Medicilon, using the Biacore 8K equipment.

JND003 is orally bioavailable and exhibits high grade of distribution in liver and abdominal adipose tissues. Pharmacokinetics (PK) and Tissue Distribution Assays of JND003 were performed at Medicilon.

美迪西藥代動力學(xué)與生物分析部主任章登吉博士將在藥代動力學(xué)研究方法與應(yīng)用技術(shù)交流會上做“高靈敏度Assay在大分子藥代動力學(xué)研究中的應(yīng)用”演講報告，歡迎觀看直播。

美迪西生物部主任毛卓博士做客云講堂，通過真實(shí)案例深入探討了PROTAC體外實(shí)驗(yàn)在構(gòu)效關(guān)系研究中的應(yīng)用，以及體外assay在推動臨床在研PROTAC分子進(jìn)程中的關(guān)鍵作用。

7月14日19：00，美迪西生物部主任毛卓博士將做客云講堂，以《如何選擇合適的體外assay進(jìn)行PROTAC分子構(gòu)效關(guān)系研究》為主題，探究PROTAC的最新研究進(jìn)展、PROTAC技術(shù)當(dāng)前挑戰(zhàn)和未來趨勢，通過真實(shí)案例探討各種PROTAC體外實(shí)驗(yàn)在構(gòu)效關(guān)系研究中的應(yīng)用、體外assay在臨床在研PROTAC分子推進(jìn)過程中的應(yīng)用等，并分享美迪西PROTAC服務(wù)平臺是如何助力客戶加速研發(fā)進(jìn)程的，用豐富的團(tuán)隊(duì)實(shí)戰(zhàn)經(jīng)驗(yàn)為您的研發(fā)答疑解惑！

7月14日19：00，美迪西生物部主任毛卓博士將做客云講堂，以《如何選擇合適的體外assay進(jìn)行PROTAC分子構(gòu)效關(guān)系研究》為主題，探究PROTAC的最新研究進(jìn)展、PROTAC技術(shù)當(dāng)前挑戰(zhàn)和未來趨勢，通過真實(shí)案例探討各種PROTAC體外實(shí)驗(yàn)在構(gòu)效關(guān)系研究中的應(yīng)用、體外assay在臨床在研PROTAC分子推進(jìn)過程中的應(yīng)用等，并分享美迪西PROTAC服務(wù)平臺是如何助力客戶加速研發(fā)進(jìn)程的，用豐富的團(tuán)隊(duì)實(shí)戰(zhàn)經(jīng)驗(yàn)為您的研發(fā)答疑解惑！

抗體藥物體內(nèi)的多種存在形式使得其PK分析方法學(xué)設(shè)計較為復(fù)雜，如何考慮待測分子形式，如何針對性地設(shè)計出合適的Assay Format，實(shí)踐中又可能出現(xiàn)什么樣的問題和挑戰(zhàn),在本文中美迪西藥代動力學(xué)與生物分析部主任章登吉博士將進(jìn)行詳細(xì)闡述。